To start the game, each player draws ten white cards.
According to the rule book provided with the game, the person who most recently “pooped” (a form of primitive randomization) begins as the “Card Czar” (or “Card Tsar”) and plays a black card, face up. The Card Czar then reads the question or fill-in-the-blanks phrase on the black card out loud.
The other players answer the question or fill in the blanks by each passing one white card (or however many required by the black card), face down, to the Card Czar.
The Card Czar shuffles all of the answers and shares each card combination with the group. For full effect, the Card Czar should usually re-read the black card before presenting each answer. The Card Czar then picks the funniest play, and whoever submitted it gets one “Awesome Point”.
After the round, a new player becomes the Card Czar, and everyone draws back up to 10 white cards.
The part of speech of a white card is a noun or gerund, including both single words and phrase constructions. Black cards are either fill-in-the-blank statements or questions. Both white and black cards break these rules on rare occasions.
The rules do not state how to win the game—the object being simply to have fun.
The rules in Cards Against Humanity are flexible and can be altered with the many house rules (which are listed in the rules) that players can incorporate (e.g. winning cards are chosen democratically, ability to trade points for cards, points given by ranks, etc.). The official rules include additional provisions for gambling previously won “Awesome Points” for the right to play additional white cards during a round.